The Cochlear Implant (CI) is the only available therapeutic solution for people affected by profound or severe sensorineural hearing loss (SNHL). Conventional CIs can bring patients back to an acceptable hearing, but they suffer from some unsurpassed disadvantages limiting the quality of life and the hearing quality after implantation. Since the damaged ear sensory cells act as biological transducers, nanostructured piezoelectric-based CI electrodes could offer new solutions and impact a large number of patients, including those suffering from mild to severe SNHL, due to reduced cost, enhanced resolution and minimally invasive surgery. PROMISE aims at developing significant advancements in the fundamental understanding of piezoelectric nanomaterials for CI. Piezoelectric self-powered devices will exploit the natural vibration and tonotopy of the cochlea and, with the generated electric charge, will be self-sufficient to stimulate the peripheral dendrites of the auditory neurons. The investigated system will consist of piezoelectric nanofibers functionalized with cell adhesion factors to create an intimate contact, at the microscale, with the basilar membrane. In addition, PROMISE system proposes an efficient integration with the biophysical microenvironment, thus reducing the necessary electric output for neural stimulation. PROMISE will increase the device sensitivity by synergizing nanotechnology, nanofabrication, biophysics, and otologic surgery procedures, so as to act at neural cell level. By empowering this multifunctional platform, PROMISE objectives are to reach proper sensitivity in order to improve treatment access by people affected by SNHL.