{"id":14705,"date":"2023-10-18T10:24:20","date_gmt":"2023-10-18T08:24:20","guid":{"rendered":"https:\/\/www.ipcf.cnr.it\/?p=14705"},"modified":"2026-03-02T18:19:42","modified_gmt":"2026-03-02T17:19:42","slug":"promise-piezoelectric-cochlear-implant-the-new-paradigm-for-sensorineural-hearing-loss","status":"publish","type":"post","link":"https:\/\/www.ipcf.cnr.it\/it\/promise-piezoelectric-cochlear-implant-the-new-paradigm-for-sensorineural-hearing-loss\/","title":{"rendered":"PROMISE- Piezoelectric cochlear implant: the new paradigm for sensorineural hearing loss"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"14705\" class=\"elementor elementor-14705\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-28be000c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"28be000c\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-402d6f3c\" data-id=\"402d6f3c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-63908b3e elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"63908b3e\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;shape_divider_top&quot;:&quot;waves&quot;}\">\n\t\t\t\t\t<div class=\"elementor-shape elementor-shape-top\" aria-hidden=\"true\" data-negative=\"false\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 1000 100\" preserveaspectratio=\"none\">\n\t<path class=\"elementor-shape-fill\" d=\"M421.9,6.5c22.6-2.5,51.5,0.4,75.5,5.3c23.6,4.9,70.9,23.5,100.5,35.7c75.8,32.2,133.7,44.5,192.6,49.7\tc23.6,2.1,48.7,3.5,103.4-2.5c54.7-6,106.2-25.6,106.2-25.6V0H0v30.3c0,0,72,32.6,158.4,30.5c39.2-0.7,92.8-6.7,134-22.4\tc21.2-8.1,52.2-18.2,79.7-24.2C399.3,7.9,411.6,7.5,421.9,6.5z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-380a766d\" data-id=\"380a766d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-3c1db04a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3c1db04a\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-7498ece6\" data-id=\"7498ece6\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-270adc2c elementor-widget elementor-widget-image\" data-id=\"270adc2c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"225\" height=\"161\" src=\"https:\/\/www.ipcf.cnr.it\/wp-content\/uploads\/2024\/05\/LOGO_-PROMISE.jpg\" class=\"attachment-large size-large wp-image-14759\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-664e281c\" data-id=\"664e281c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-158fc32b elementor-widget elementor-widget-text-editor\" data-id=\"158fc32b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Durata:<\/strong> 18 Oct 2023 &#8211; 28 Feb 2026 (2 years, 4 months)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8fdc12a elementor-widget elementor-widget-text-editor\" data-id=\"8fdc12a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Ente finanziatore:<\/b>\u00a0<a href=\"https:\/\/prin.mur.gov.it\/Iniziative\/Detail?key=FiJNdaCuA71Xq3jYMAuZeQ%3D%3D\" target=\"_blank\" rel=\"nofollow noopener\"><span style=\"font-family: 'Times New Roman', serif; font-size: 11pt; font-weight: var( --e-global-typography-text-font-weight );\">Ministero dell&#8217;Universit\u00e0 e della Ricerca (MUR) &#8211; PRIN 2022<\/span><\/a> &#8211; 2022JYHMPF<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3da08026 elementor-widget elementor-widget-text-editor\" data-id=\"3da08026\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Principal Investigator:<\/strong> Stefano Berrettini (University of Pisa)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-531a9cdf elementor-widget elementor-widget-text-editor\" data-id=\"531a9cdf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Referente IPCF:\u00a0<\/strong><a href=\"https:\/\/www.ipcf.cnr.it\/it\/team\/massimiliano-labardi\/\" target=\"_blank\" rel=\"noopener\">M. Labardi<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a2cde55 elementor-widget elementor-widget-text-editor\" data-id=\"a2cde55\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Sito web:\u00a0<\/strong><a href=\"http:\/\/promise.ipcf.cnr.it\/\" target=\"_blank\" rel=\"noopener\">promise<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-2ed8af30 elementor-widget elementor-widget-spacer\" data-id=\"2ed8af30\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6257e8db elementor-widget elementor-widget-text-editor\" data-id=\"6257e8db\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Settore ERC: <\/b>LS5_7 Sensory systems, sensation and perception, including pain<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4cf37c71 elementor-widget elementor-widget-text-editor\" data-id=\"4cf37c71\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Parole chiave: <\/b>Nanotechnology; Piezoelectricity; Nanofibers; Cochlear implant; Tissue engineering<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-63ff637 elementor-widget elementor-widget-text-editor\" data-id=\"63ff637\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The Cochlear Implant (CI) is the only available therapeutic solution for people affected by profound or severe sensorineural hearing loss (SNHL). Conventional CIs can bring patients back to an acceptable hearing, but they suffer from some unsurpassed disadvantages limiting the quality of life and the hearing quality after implantation. Since the damaged ear sensory cells act as biological transducers, nanostructured piezoelectric-based CI electrodes could offer new solutions and impact a large number of patients, including those suffering from mild to severe SNHL, due to reduced cost, enhanced resolution and minimally invasive surgery. PROMISE aims at developing significant advancements in the fundamental understanding of piezoelectric nanomaterials for CI. Piezoelectric self-powered devices will exploit the natural vibration and tonotopy of the cochlea and, with the generated electric charge, will be self-sufficient to stimulate the peripheral dendrites of the auditory neurons. The investigated system will consist of piezoelectric nanofibers functionalized with cell adhesion factors to create an intimate contact, at the microscale, with the basilar membrane. In addition, PROMISE system proposes an efficient integration with the biophysical microenvironment, thus reducing the necessary electric output for neural stimulation. PROMISE will increase the device sensitivity by synergizing nanotechnology, nanofabrication, biophysics, and otologic surgery procedures, so as to act at neural cell level. By empowering this multifunctional platform, PROMISE objectives are to reach proper sensitivity in order to improve treatment access by people affected by SNHL.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Duration: 18 Oct 2023 &#8211; 28 Feb 2026 (2 years, 4 months) Funding Institution:\u00a0Ministero dell&#8217;Universit\u00e0 e della Ricerca (MUR) &#8211; PRIN 2022 &#8211; 2022JYHMPF Principal Investigator: Stefano Berrettini (University of Pisa) Contact person in IPCF:\u00a0M. Labardi Website:\u00a0promise ERC Sector: LS5_7 Sensory systems, sensation and perception, including pain Keywords: Nanotechnology; Piezoelectricity; Nanofibers; Cochlear implant; Tissue engineering [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":14758,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[102,112,107,105,103,97],"tags":[],"post_formats":[],"class_list":["post-14705","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-closed-projects","category-national","category-pnrr","category-prin","category-prin2022","category-projects"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.10 - aioseo.com -->\n\t<meta name=\"description\" content=\"Duration: 18 Oct 2023 \u2013 28 Feb 2026 (2 years, 4 months) Funding Institution: Ministero dell\u2019Universit\u00e0 e della Ricerca (MUR) \u2013 PRIN 2022 \u2013 2022JYHMPF Principal Investigator: Stefano Berrettini (University of Pisa) Contact person in IPCF: M. 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