{"id":14255,"date":"2023-12-01T15:08:25","date_gmt":"2023-12-01T14:08:25","guid":{"rendered":"https:\/\/www.ipcf.cnr.it\/?p=14255"},"modified":"2024-05-07T20:58:21","modified_gmt":"2024-05-07T18:58:21","slug":"nanocrystalline-hydroxyapatite-for-the-local-delivery-of-anticancer-agents-in-the-treatment-of-bone-tumors-and-metastases","status":"publish","type":"post","link":"https:\/\/www.ipcf.cnr.it\/it\/nanocrystalline-hydroxyapatite-for-the-local-delivery-of-anticancer-agents-in-the-treatment-of-bone-tumors-and-metastases\/","title":{"rendered":"NHYLODEA &#8211; Nanocrystalline HYdroxyapatite for the LOcal DElivery of Anticancer agents in the treatment of bone tumors and metastases"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"14255\" class=\"elementor elementor-14255\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-19a1edad elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"19a1edad\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-57a44f6\" data-id=\"57a44f6\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-79311a10 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"79311a10\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;shape_divider_top&quot;:&quot;waves&quot;}\">\n\t\t\t\t\t<div class=\"elementor-shape elementor-shape-top\" aria-hidden=\"true\" data-negative=\"false\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 1000 100\" preserveaspectratio=\"none\">\n\t<path class=\"elementor-shape-fill\" d=\"M421.9,6.5c22.6-2.5,51.5,0.4,75.5,5.3c23.6,4.9,70.9,23.5,100.5,35.7c75.8,32.2,133.7,44.5,192.6,49.7\tc23.6,2.1,48.7,3.5,103.4-2.5c54.7-6,106.2-25.6,106.2-25.6V0H0v30.3c0,0,72,32.6,158.4,30.5c39.2-0.7,92.8-6.7,134-22.4\tc21.2-8.1,52.2-18.2,79.7-24.2C399.3,7.9,411.6,7.5,421.9,6.5z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1c9a7234\" data-id=\"1c9a7234\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-7e2f29e6 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7e2f29e6\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-11562ceb\" data-id=\"11562ceb\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-52b0ad83 elementor-widget elementor-widget-image\" data-id=\"52b0ad83\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"640\" height=\"524\" src=\"https:\/\/www.ipcf.cnr.it\/wp-content\/uploads\/2024\/05\/Immagine2.jpg\" class=\"attachment-large size-large wp-image-14447\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-4ed1f049\" data-id=\"4ed1f049\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-545e2ea8 elementor-widget elementor-widget-text-editor\" data-id=\"545e2ea8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Durata:<\/strong> From 1 Dec 2023 &#8211; 30 Nov 2025 (2 years)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4f8e4f56 elementor-widget elementor-widget-text-editor\" data-id=\"4f8e4f56\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Ente finanziatore:<\/b>\u00a0<a href=\"https:\/\/prin.mur.gov.it\/Iniziative\/Detail?key=xntlwCEQJ%2BTLxeoukrh%2FdQ%3D%3D\" target=\"_blank\" rel=\"nofollow noopener\">Ministero dell&#8217;Universit\u00e0 e della Ricerca (MUR) &#8211; PRIN 2022PNRR<\/a> &#8211; P2022RLFZB<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-679ecc8d elementor-widget elementor-widget-text-editor\" data-id=\"679ecc8d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Principal Investigator:<\/strong> Nicola Margiotta (Universit\u00e0 degli Studi di Bari)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-51788f66 elementor-widget elementor-widget-text-editor\" data-id=\"51788f66\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Referente IPCF:\u00a0<\/strong><a href=\"https:\/\/www.ipcf.cnr.it\/it\/team\/nicoletta-depalo\/\" target=\"_blank\" rel=\"nofollow noopener\">Nicoletta Depalo<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8e397b4 elementor-widget elementor-widget-text-editor\" data-id=\"8e397b4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Unit\u00e0 di ricerca coinvolte (referente):<\/strong>\u00a0 Universit\u00e0 degli Studi di Palermo (Alessio Terenzi)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-11e91b20 elementor-widget elementor-widget-spacer\" data-id=\"11e91b20\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5fd5beb2 elementor-widget elementor-widget-text-editor\" data-id=\"5fd5beb2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Settori ERC:\u00a0<\/b>PE5_9 Coordination chemistry; PE5_7 Biomaterials synthesis; LS7_7 Pharmacology and toxicology; PE5_9 Chimica di coordinazione; PE5_7 Sintesi di biomateriali;LS7_7 Farmacologia e tossicologia<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2e30a2a6 elementor-widget elementor-widget-text-editor\" data-id=\"2e30a2a6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Parole chiave: <\/b>Platinum Complexes, Hydroxyapatite nanoparticles, Mesoporous silica nanoparticles, Bisphosphonates, Bone tumors.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-64ce0478 elementor-widget elementor-widget-text-editor\" data-id=\"64ce0478\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The project aims to develop novel biomaterials based on hydroxyapatite and mesoporous silica, loaded with newly designed chemotherapeutic agents specifically tailored for bone cancer and metastases, to be administered in situ following resection of the bone tumour or metastasis and implantation via injection of a bone substitute biomaterial. The objective is to overcome the limitations and side effects of conventional systemic administration of chemotherapeutic agents used in the treatment of bone cancer, including metastatic forms. Therefore, nanostructures loaded with chemotherapeutic agents, based on cisplatin, will be designed, prepared, and characterized at each preparatory step, from a structural, morphological, dimensional, compositional, drug loading, and release capacity perspective. Additionally, biodegradation experiments and studies on cell cultures will be conducted to evaluate the therapeutic efficacy of the new nano-biomaterials.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Duration: From 1 Dec 2023 &#8211; 30 Nov 2025 (2 years) Funding Institution:\u00a0Ministero dell&#8217;Universit\u00e0 e della Ricerca (MUR) &#8211; PRIN 2022PNRR &#8211; P2022RLFZB Principal Investigator: Nicola Margiotta (Universit\u00e0 degli Studi di Bari) Contact person in IPCF:\u00a0Nicoletta Depalo Other research units (contact person):\u00a0 Universit\u00e0 degli Studi di Palermo (Alessio Terenzi) Settori ERC:\u00a0PE5_9 Coordination chemistry; PE5_7 Biomaterials [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":14446,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[101,112,107,105,104,97],"tags":[],"post_formats":[],"class_list":["post-14255","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-active-projects","category-national","category-pnrr","category-prin","category-prin-pnrr","category-projects"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.8 - aioseo.com -->\n\t<meta name=\"description\" content=\"Duration: From 1 Dec 2023 \u2013 30 Nov 2025 (2 years) Funding Institution: Ministero dell\u2019Universit\u00e0 e della Ricerca (MUR) \u2013 PRIN 2022PNRR \u2013 P2022RLFZB Principal Investigator: Nicola Margiotta (Universit\u00e0 degli Studi di Bari) Contact person in IPCF: Nicoletta Depalo Other research units (contact person): Universit\u00e0 degli Studi di Palermo (Alessio Terenzi) Settori ERC: PE5_9 Coordination chemistry; 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