{"id":14114,"date":"2023-10-16T11:31:49","date_gmt":"2023-10-16T09:31:49","guid":{"rendered":"https:\/\/www.ipcf.cnr.it\/?p=14114"},"modified":"2026-03-21T14:37:28","modified_gmt":"2026-03-21T13:37:28","slug":"semper-synthetically-engineered-emissive-peptide-nucleic-acids-pna-for-medical-diagnostics-based-on-optical-and-surface-enhanced-raman-techniques","status":"publish","type":"post","link":"https:\/\/www.ipcf.cnr.it\/it\/semper-synthetically-engineered-emissive-peptide-nucleic-acids-pna-for-medical-diagnostics-based-on-optical-and-surface-enhanced-raman-techniques\/","title":{"rendered":"SEMPER &#8211; Synthetically Engineered EMissive Peptide nucleic acids (PNA) for Medical Diagnostics based on Optical and Surface-Enhanced Raman Techniques"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"14114\" class=\"elementor elementor-14114\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7c3bad56 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7c3bad56\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-62c66606\" data-id=\"62c66606\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5e2452 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5e2452\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;shape_divider_top&quot;:&quot;waves&quot;}\">\n\t\t\t\t\t<div class=\"elementor-shape elementor-shape-top\" aria-hidden=\"true\" data-negative=\"false\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 1000 100\" preserveaspectratio=\"none\">\n\t<path class=\"elementor-shape-fill\" d=\"M421.9,6.5c22.6-2.5,51.5,0.4,75.5,5.3c23.6,4.9,70.9,23.5,100.5,35.7c75.8,32.2,133.7,44.5,192.6,49.7\tc23.6,2.1,48.7,3.5,103.4-2.5c54.7-6,106.2-25.6,106.2-25.6V0H0v30.3c0,0,72,32.6,158.4,30.5c39.2-0.7,92.8-6.7,134-22.4\tc21.2-8.1,52.2-18.2,79.7-24.2C399.3,7.9,411.6,7.5,421.9,6.5z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-17f889c\" data-id=\"17f889c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-70ca0b84 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"70ca0b84\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-62905694\" data-id=\"62905694\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-54257108 elementor-widget elementor-widget-image\" data-id=\"54257108\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"225\" height=\"161\" src=\"https:\/\/www.ipcf.cnr.it\/wp-content\/uploads\/2024\/04\/LOGO_SEMPER.jpg\" class=\"attachment-large size-large wp-image-14126\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-62967b67\" data-id=\"62967b67\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-38ca63b9 elementor-widget elementor-widget-text-editor\" data-id=\"38ca63b9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Durata:<\/strong> From 16 Oct 2023 &#8211; 28 Feb 2026 (2 years, 4 months)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2dd0683a elementor-widget elementor-widget-text-editor\" data-id=\"2dd0683a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Ente finanziatore:<\/b>\u00a0<a href=\"https:\/\/prin.mur.gov.it\/Iniziative\/Detail?key=FiJNdaCuA71Xq3jYMAuZeQ%3D%3D\" target=\"_blank\" rel=\"nofollow noopener\">Ministero dell&#8217;Universit\u00e0 e della Ricerca (MUR) &#8211; PRIN 2022<\/a> &#8211; 20227ZXT4Z<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-56607920 elementor-widget elementor-widget-text-editor\" data-id=\"56607920\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Principal Investigator:<\/strong> Andrea Fin (University of Torino)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-67dd9564 elementor-widget elementor-widget-text-editor\" data-id=\"67dd9564\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Referente IPCF:<\/strong> <a href=\"https:\/\/www.ipcf.cnr.it\/it\/team\/nino-foti\/\" target=\"_blank\" rel=\"nofollow noopener\">A. Foti<\/a> (Vice PI)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-288a4cd7 elementor-widget elementor-widget-text-editor\" data-id=\"288a4cd7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Unit\u00e0 di ricerca coinvolte (referente):<\/strong> University of Torino (Andrea Fin); Politecnico di Torino (Fabrizio Giorgis)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-58ba07a9 elementor-widget elementor-widget-spacer\" data-id=\"58ba07a9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-598093be elementor-widget elementor-widget-text-editor\" data-id=\"598093be\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Settori ERC: <\/b>PE5_17 Organic chemistry; PE3_10 Nanophysics, e.g. nanoelectronics, nanophotonics, nanomagnetism, nanoelectromechanics; LS7_2 Medical technologies and tools (including genetic tools and biomarkers) for prevention, diagnosis, monitoring and treatment of diseases<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7272d42b elementor-widget elementor-widget-text-editor\" data-id=\"7272d42b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Parole chiave: <\/b>Peptide Nucleic Acids; Nanophotonics; Surface enhanced Raman scattering and optical tweezing; Fluorescence Spectroscopy; Organic-inorganic hybrids; miRNA cancer biomarker.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1902adbd elementor-widget elementor-widget-text-editor\" data-id=\"1902adbd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The project aims to develop innovative detection techniques for the quantification of miRNA at low concentration (fM) based on both on fluorescence and SERS spectroscopy of intrinsically emissive peptide nucleic acids (PNA) and PNA tagged with naphthalenediimides (NDI), which bind specifically to miRNA sequences. The detection strategy will be implemented with optical manipulation techniques (optical tweezers), also within microfluidic circuits.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4b98fd elementor-widget elementor-widget-text-editor\" data-id=\"4b98fd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Research Postdoc hired on the project: <\/strong><a href=\"https:\/\/www.ipcf.cnr.it\/it\/team\/rayhane-zribi\/\" target=\"_blank\" rel=\"nofollow noopener\">Rayhane Zribi<\/a><\/p><p><strong>Altro personale IPCF coinvolto nelle attivit\u00e0 di ricerca:<\/strong> <a href=\"http:\/\/www.ipcf.cnr.it\/it\/team\/maria-grazia-donato\/\" target=\"_blank\" rel=\"noopener\">M. G. Donato<\/a>,\u00a0<a href=\"http:\/\/www.ipcf.cnr.it\/it\/team\/pietro-giuseppe-gucciardi\/\" target=\"_blank\" rel=\"noopener\">P. G. Gucciardi<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Duration: From 16 Oct 2023 &#8211; 28 Feb 2026 (2 years, 4 months) Funding Institution:\u00a0Ministero dell&#8217;Universit\u00e0 e della Ricerca (MUR) &#8211; PRIN 2022 &#8211; 20227ZXT4Z Principal Investigator: Andrea Fin (University of Torino) Contact person in IPCF: A. Foti (Vice PI) Other research units (contact person): University of Torino (Andrea Fin); Politecnico di Torino (Fabrizio Giorgis) [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":14115,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[102,112,107,105,103,97],"tags":[],"post_formats":[],"class_list":["post-14114","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-closed-projects","category-national","category-pnrr","category-prin","category-prin2022","category-projects"],"aioseo_notices":[],"guten_post_layout_featured_media_urls":{"full":["https:\/\/www.ipcf.cnr.it\/wp-content\/uploads\/2024\/04\/semper_ev.png",300,300,false],"thumbnail":["https:\/\/www.ipcf.cnr.it\/wp-content\/uploads\/2024\/04\/semper_ev.png",150,150,false],"medium":["https:\/\/www.ipcf.cnr.it\/wp-content\/uploads\/2024\/04\/semper_ev.png",300,300,false],"medium_large":["https:\/\/www.ipcf.cnr.it\/wp-content\/uploads\/2024\/04\/semper_ev.png",300,300,false],"large":["https:\/\/www.ipcf.cnr.it\/wp-content\/uploads\/2024\/04\/semper_ev.png",300,300,false],"1536x1536":["https:\/\/www.ipcf.cnr.it\/wp-content\/uploads\/2024\/04\/semper_ev.png",300,300,false],"2048x2048":["https:\/\/www.ipcf.cnr.it\/wp-content\/uploads\/2024\/04\/semper_ev.png",300,300,false],"trp-custom-language-flag":["https:\/\/www.ipcf.cnr.it\/wp-content\/uploads\/2024\/04\/semper_ev.png",12,12,false],"wpca-thumb":["https:\/\/www.ipcf.cnr.it\/wp-content\/uploads\/2024\/04\/semper_ev.png",150,150,false],"guten_post_layout_landscape_large":["https:\/\/www.ipcf.cnr.it\/wp-content\/uploads\/2024\/04\/semper_ev.png",300,300,false],"guten_post_layout_portrait_large":["https:\/\/www.ipcf.cnr.it\/wp-content\/uploads\/2024\/04\/semper_ev.png",300,300,false],"guten_post_layout_square_large":["https:\/\/www.ipcf.cnr.it\/wp-content\/uploads\/2024\/04\/semper_ev.png",300,300,false],"guten_post_layout_landscape":["https:\/\/www.ipcf.cnr.it\/wp-content\/uploads\/2024\/04\/semper_ev.png",300,300,false],"guten_post_layout_portrait":["https:\/\/www.ipcf.cnr.it\/wp-content\/uploads\/2024\/04\/semper_ev.png",300,300,false],"guten_post_layout_square":["https:\/\/www.ipcf.cnr.it\/wp-content\/uploads\/2024\/04\/semper_ev.png",300,300,false],"academix-single-team-thumb":["https:\/\/www.ipcf.cnr.it\/wp-content\/uploads\/2024\/04\/semper_ev.png",270,270,false],"academix-team-thumbnail":["https:\/\/www.ipcf.cnr.it\/wp-content\/uploads\/2024\/04\/semper_ev.png",216,216,false],"academix-event-thumbnail":["https:\/\/www.ipcf.cnr.it\/wp-content\/uploads\/2024\/04\/semper_ev.png",300,300,false],"academix-event-gallery-thumb":["https:\/\/www.ipcf.cnr.it\/wp-content\/uploads\/2024\/04\/semper_ev.png",168,168,false],"academix-blog-thumb":["https:\/\/www.ipcf.cnr.it\/wp-content\/uploads\/2024\/04\/semper_ev.png",80,80,false]},"_links":{"self":[{"href":"https:\/\/www.ipcf.cnr.it\/it\/wp-json\/wp\/v2\/posts\/14114","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ipcf.cnr.it\/it\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ipcf.cnr.it\/it\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ipcf.cnr.it\/it\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ipcf.cnr.it\/it\/wp-json\/wp\/v2\/comments?post=14114"}],"version-history":[{"count":31,"href":"https:\/\/www.ipcf.cnr.it\/it\/wp-json\/wp\/v2\/posts\/14114\/revisions"}],"predecessor-version":[{"id":18533,"href":"https:\/\/www.ipcf.cnr.it\/it\/wp-json\/wp\/v2\/posts\/14114\/revisions\/18533"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ipcf.cnr.it\/it\/wp-json\/wp\/v2\/media\/14115"}],"wp:attachment":[{"href":"https:\/\/www.ipcf.cnr.it\/it\/wp-json\/wp\/v2\/media?parent=14114"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ipcf.cnr.it\/it\/wp-json\/wp\/v2\/categories?post=14114"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ipcf.cnr.it\/it\/wp-json\/wp\/v2\/tags?post=14114"},{"taxonomy":"post_format","embeddable":true,"href":"https:\/\/www.ipcf.cnr.it\/it\/wp-json\/wp\/v2\/post_formats?post=14114"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}