Istituto per i Processi Chimico Fisici

Personal information

Name,
Surname

Monica, Boffito

Address

House
number, street name, postcode, city, country

Strada Rivarola, 11

15060, Capriata d’Orba (AL)

Telephone

Fax

–

E-mail

monica.boffito@polito.it

Website

–

Nationality

Italian

Place and
Date of birth

Novi
Ligure (AL), 24/04/1986

Work experience

In  ordine di data /Dates (from – to)

January
2017 – Present

Nome e indirizzo del datore di lavoro / Name and
address of employ

Politecnico di Torino

Dipartimento di Ingegneria Meccanica e Aerospaziale

Corso Duca degli Abruzzi 24

10129 Torino

Tipo o settore di attività / Type of business or sector

Funzione o posto occupato / Occupation or position held

Assistant Professor

Principali mansion e responsabilità / Main activities and
responsibilities

– Synthesis and
characterization of biomimetic polyurethanes and their application in the
design of injectable hydrogels or cellularized scaffolds through conventional
and advanced fabrication technologies for soft tissue
engineering/regenerative medicine applications.

– Design of injectable thermosensitive hydrogels for the release of
mesoporous matrices loaded with therapeutic ions and drugs. (H2020-NMP6-2015
project MOZART “MesopOrous matrices for localized pH-triggered release
of therapeutic ions and drugs”)

January 2014 – December 2016

Politecnico di Torino

Dipartimento di Ingegneria Meccanica e Aerospaziale

Corso Duca degli Abruzzi 24

10129 Torino

Post-Doc Fellow (Supervisor: Prof. Gianluca Ciardelli)

– Synthesis and
characterization of biomimetic polyurethanes and their application in the
design of cellularized scaffolds and injectable hydrogels for cardiac tissue
engineering/regenerative medicine. (FIRB2010 Project Dr. Valeria Chiono
“Bioartificial materials and biomimetic scaffolds for a stem cells-based
therapy for myocardial regeneration”, collaboration with the Swiss Stem
Cell Foundation (Switzerland) (Dr. Gianni Soldati)).

– Design of injectable
thermosensitive hydrogels for the release of mesoporous matrices loaded with
therapeutic ions and drugs. (H2020-NMP6-2015 project MOZART “MesopOrous
matrices for localized pH-triggered release of therapeutic ions and
drugs”)

January
2011 – December 2013

Politecnico di Torino

Dipartimento di Ingegneria Meccanica e Aerospaziale

Corso Duca degli Abruzzi 24

10129 Torino

PhD in BIOMEDICAL
ENGINEERING (XXVI cycle) (Supervisor:
Prof. Gianluca Ciardelli)

– Design of biomimetic
polyurethane-based scaffolds and injectable hydrogels for cardiac tissue
engineering/regenerative medicine application. (FIRB2010 Project Dr. Valeria
Chiono “Bioartificial materials and biomimetic scaffolds for a stem
cells-based therapy for myocardial regeneration”, collaboration with the
Swiss Stem Cell Foundation (Switzerland) (Dr. Gianni Soldati), project POR
“Piattaforme Innovative” (F.E:S.R. 2007-2013) “ACTIVE-Advanced
Cardiovascular Therapies”)

Education and training

Dates (from – to)

January 2011 – December 2013

Name and type of organisation providing education and training

PhD in BIOMEDICAL
ENGINEERING (XXVI cycle) (Supervisor:
Prof. Gianluca Ciardelli)

Politecnico di Torino

Dipartimento di Ingegneria Meccanica e Aerospaziale

Corso Duca degli Abruzzi 24

10129 Torino

Principal subjects  occupational
skills covered

Thesis:
“Bioengineered Patches in the Regeneration of Infarcted Myocardial
Tissue” (Supervisor: Prof. Gianluca Ciardelli)

Title of qualification awarded

Level in National classification

September 2008 – December 2010

Master Degree in
BIOMEDICAL ENGINEERING

Politecnico di Torino

Dipartimento di Ingegneria Meccanica e Aerospaziale

Corso Duca degli Abruzzi 24

10129 Torino

Thesis: “Biomimetic strategies for cardiac
tissue repair” (Supervisor: Prof. Gianluca Ciardelli) (110 cum Laude /
110)

September 2005
– July 2008

Bachelor Degree in BIOMEDICAL ENGINEERING

Politecnico di Torino

Dipartimento di Ingegneria Meccanica e Aerospaziale

Corso Duca degli Abruzzi 24

10129 Torino

Thesis: “Design and realization of implantable
medical devices for surgical reconstruction: BT interference screw”
(Supervisor: Prof. Gianluca Ciardelli) (110/110)

Attivita’ di ricerca / Research
activities

Research
sectors

– material design

– tissue engineering/regenerative
medicine

– surface and bulk
functionalization

– design and fabrication of 3D
porous scaffolds

– design of stimuli-sensitive
hydrogels

– drug release

– conventional scaffold
fabrication techniques

– advanced fabrication
technologies (fused deposition modeling, bioprinting)

Recent
Scientific Activities.

– Design of injectable
thermosensitive hydrogels for the release of mesoporous matrices loaded with
therapeutic ions and drugs. (H2020-NMP6-2015 project MOZART “MesopOrous
matrices for localized pH-triggered release of therapeutic ions and
drugs”)

– Design
of thermo- and photo-sensitive hydrogels for the bioprinting of cellularized
constructs (A*STAR Research Attachment
Programme, Novel biomimetic
scaffolds inducing stem cell fate: application in tissue engineering
(BIOSTEM) (2016-2018), coordinator Prof. Gianluca Ciardelli, Dr. May
Win Naing)

Books and
Articles

C. Mattu, M. Boffito, S. Sartori, E. Ranzato, E.
Bernardi, M. P. Sassi, A. M. Di Rienzo, G. Ciardelli. Journal of
Nanoparticle Research, 2012, 14, 1306.

A.
Silvestri, M. Boffito, S. Sartori, G. Ciardelli. Macromolecular Bioscience,
2013, 8, 984-1019.

C. Mattu, R. Pabari, M. Boffito, S. Sartori, G.
Ciardelli, Z. Ramtoola. European
Journal of Pharmaceutics and Biopharmaceutics, 2013, 85, 463-472.

S. Sartori, M. Boffito, P. Serafini, A. Caporale, A.
Silvestri, E. Bernardi, M. P. Sassi, F. Boccafoschi, G. Ciardelli. Reactive and
Functional Polymers, 2013, 73, 1366–1376.

M.
Boffito, S. Sartori, G. Ciardelli. Polymer International, 2014, 63, 2-11.

V. Chiono, P. Mozetic, M. Boffito, S. Sartori, E.
Gioffredi, A. Silvestri, A. Rainer, S. M. Giannitelli, M. Trombetta, D.
Nurzynska, F. Di Meglio, C. Castaldo, R. Miraglia, S. Montagnani, G.
Ciardelli. Interface Focus, 2014, 4, 2042-8901.

E. Gioffredi, M. Boffito,
S. Calzone, S. M. Giannitelli, A. Rainer, M. Trombetta, P. Mozetic, V.Chiono.
Procedia CIRP, 2016, 49, 125-132.

M. Boffito, E. Gioffredi,
V. Chiono, S. Calzone, E. Ranzato, S. Martinotti, G. Ciardelli. Polymer
International, 2016, 65, 756-769.

C. Tonda-Turo, M. Boffito, C. Cassino, P. Gentile, G. Ciardelli.
Materials Letter, 2016, 167, 9-12.

Additional information

M. Boffito, S. Sartori, C. Mattu G. Ciardelli. Polyurethanes
for cardiac applications. Chapter 13 in “Advances in Polyurethane
Biomaterials” (ISBN: 978-0-08-100614-6). Eds. S. Cooper and J. Guan, 1st
Edition, Woodhead Publishing, United Kingdom, 2016

V. Chiono, S. Sartori, S. Calzone, M. Boffito, C. Tonda-Turo, C. Mattu,
P. Gentile, G. Ciardelli. Synthetic
biodegradable medical polyurethanes. Chapter 8 in “Science and
principles of biodegradable and bioresorbable medical polymers: Materials and
properties” (ISBN: 9780081003930). Eds. Z. Xiang, Woodhead Publishing,
United Kingdom, 2016.

S. Caddeo, M. Boffito, S. Sartori. Front
Bioeng Biotechnol. 2017, 26, 40.

Patents:

– V. Chiono, P. Mozetic, S. M. Giannitelli, A. Rainer, M. Trombetta, M.
Boffito, E. Gioffredi, S. Sartori. Metodo per la preparazione di costrutti
cellularizzati a base di idrogeli termosensibili. Patent n° 102015000020718,
2015

– G. Ciardelli, S. Sartori, M. Boffito, P. M. Serafini. Heat-sensitive amphiphilic polyurethanes and aqueous
solutions capable of being injected based on such materials. Patent n°
TO2012A000669, 2012

Awards:

– PhD thesis award
“Enzo Belardinelli” (6° ed.) with the word titled “Biomimetic
strategies for cardiac tissue repair”.

– Best oral presentation
-3rd place- at TERMIS-EU- 2014 (Genova, 10-13 June 2014) with the work
entitled “Cellularized polyurethane-based scaffolds to repair the
infarcted myocardial tissue”.

– Best poster presentation
at National SIB Congress 2013 (Baveno, 3-5 June, 2013) with the work entitled
“Polyurethane-based Scaffolds for the Regeneration of the Infarcted
Myocardial Tissue”.

– Master thesis award
“GRUPPO NAZIONALE DI BIOINGEGNERIA” (12° ed.) with the work
entitled “Biomimetic strategies for cardiac tissue repair”.